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Tirzepatide 3ml vial label
Weight ManagementPurity 99.0%
Product profile

Tirzepatide

Dual GIP/GLP-1 receptor agonist for metabolic research.

99.0%
Purity
Lyophilized
Form
-20°C
Storage
Research Use Only. Not for human or veterinary consumption, diagnostic, or therapeutic use.

What it is

Tirzepatide engages both GIP and GLP-1 receptors, of interest in metabolic and glycemic research models.

Pathway Diagram

Mechanism of Action

CRL · MOA-01

Dual incretin receptor activation enhances glucose-dependent insulin response and modulates appetite-regulating pathways.

  1. Step 01
    Receptor Binding

    Peptide engages target receptor with high affinity.

  2. Step 02
    Signal Cascade

    Downstream intracellular pathways activate.

  3. Step 03
    Cellular Response

    Gene expression and protein synthesis shift.

  4. Step 04
    Observed Outcome

    Measurable change in the studied biomarker.

Primary TargetsGlucose homeostasisAppetite signaling studiesAdipocyte differentiation

Research highlights

Dual GIP/GLP-1 receptor agonist — first-in-class incretin co-agonist.
SURMOUNT-1 reported up to ~22.5% weight reduction at 72 weeks.
Superior glycemic control vs. semaglutide in head-to-head SURPASS-2.
Once-weekly dosing supported by ~5-day half-life.

Pharmacology snapshot

4813.5 Da
Molecular weight
~5 days
Half-life
Weekly SC (research)
Route (research)

Potential research applications

Glucose homeostasis
Appetite signaling studies
Adipocyte differentiation
Cardiometabolic research

Case studies

Clinical72 weeks

SURMOUNT-1 obesity trial

Cohort: 2539 adults with obesity

Phase 3 study of tirzepatide 5, 10, 15 mg vs. placebo on body weight in adults without diabetes.

Outcome

Mean weight reductions of −15.0%, −19.5%, −20.9% across doses vs. −3.1% placebo.

Jastreboff et al., NEJM 2022;387(3):205–216
Clinical40 weeks

SURPASS-2 vs. semaglutide

Cohort: 1879 adults with T2D

Head-to-head tirzepatide vs. semaglutide 1 mg in inadequately controlled T2D.

Outcome

Superior HbA1c reduction across all doses and greater weight loss vs. semaglutide.

Frías et al., NEJM 2021;385(6):503–515
Clinical40 weeks

SURPASS-1 monotherapy

Cohort: 478 adults with T2D

Tirzepatide monotherapy vs. placebo as first-line pharmacotherapy.

Outcome

HbA1c reductions of 1.87–2.07% with weight loss of 7.0–9.5 kg.

Rosenstock et al., Lancet 2021;398(10295):143–155
Handling Protocol

Storage Guidelines

CRL · STR-02

Refrigerate post-reconstitution at 2–8°C. Lyophilized -20°C, light-protected.

Lyophilized
-20°C
Long-term, 24 months
Reconstituted
2–8°C
Refrigerated, 28 days
Light Exposure
Protect
Store in dark vial
Diluent
BAC Water
Sterile, 0.9% benzyl
Best practice — reconstitute with bacteriostatic water, swirl gently, do not shake.
Regulatory Notice

Research Disclaimer

CRL · REG-03
Research Use Only

Strictly for in-vitro laboratory and research investigations.

Not For Human Use

Not approved for diagnostic, therapeutic, or veterinary application.

Qualified Personnel

Handling restricted to licensed researchers and laboratory staff.

Warning — Tirzepatide is supplied solely for legitimate laboratory research. Any administration to humans or animals is strictly prohibited and may violate federal, state, or local law. By purchasing, the researcher accepts full responsibility for safe handling, storage, and lawful use.

Document · CRL-REG-03Revision 2026.06 · Clinical Research Labs
Representative Literature

Citations & References

CRL · REF-04
  1. 02
    Jastreboff AM, Aronne LJ, Ahmad NN, et al. · 2022
    Tirzepatide once weekly for the treatment of obesity
    New England Journal of Medicine. 387(3):205–216.
  2. 03
    Frías JP, Davies MJ, Rosenstock J, et al. · 2021
    Tirzepatide versus semaglutide once weekly in patients with type 2 diabetes
    New England Journal of Medicine. 385(6):503–515.
References are representative of peer-reviewed literature and are provided for research context only.
Document · CRL-REF-04Revision 2026.06 · Clinical Research Labs