Back to catalog
Thymosin Alpha-1 3ml vial label
ImmunePurity 99.3%
Product profile

Thymosin Alpha-1

Thymic 28-mer peptide for immunomodulation research.

99.3%
Purity
Lyophilized
Form
-20°C
Storage
Research Use Only. Not for human or veterinary consumption, diagnostic, or therapeutic use.

What it is

Thymosin alpha-1 is a 28-amino-acid peptide derived from prothymosin alpha, used in research of T-cell maturation and innate-immune modulation.

Pathway Diagram

Mechanism of Action

CRL · MOA-01

Engages TLR2/TLR9 pathways and modulates dendritic-cell maturation, T-cell differentiation, and cytokine balance.

  1. Step 01
    Receptor Binding

    Peptide engages target receptor with high affinity.

  2. Step 02
    Signal Cascade

    Downstream intracellular pathways activate.

  3. Step 03
    Cellular Response

    Gene expression and protein synthesis shift.

  4. Step 04
    Observed Outcome

    Measurable change in the studied biomarker.

Primary TargetsImmunomodulation researchViral infection modelsOncology immune studies

Research highlights

28-amino-acid peptide cleaved from prothymosin alpha.
Modulates dendritic-cell maturation via TLR2/TLR9.
Approved in many countries as immunomodulator (Zadaxin).
Investigated in viral infection, vaccine response, and oncology research.

Pharmacology snapshot

3108.3 Da
Molecular weight
~2 hours
Half-life
SC (research)
Route (research)

Potential research applications

Immunomodulation research
Viral infection models
Oncology immune studies
Vaccine adjuvant research

Case studies

PreclinicalMulti-week

DC activation via TLR signaling

Cohort: Murine fungal infection model

Tested Tα1 effects on dendritic cells and antifungal Th1 resistance.

Outcome

Activated DC maturation and Th1-skewed response vs. control.

Romani et al., Blood 2004;103(11):4232–4239
ClinicalMulti-month

Tα1 in oncology combinations

Cohort: Cross-trial synthesis

Reviewed Tα1 combined with cytokines/chemotherapy across cancers.

Outcome

Documented improved response and tolerability signals across regimens.

Garaci et al., Int Immunopharmacol 2003;3(8):1145–1150
Clinical

Historical review in infectious disease

Cohort: Multi-decade synthesis

Historical review of Tα1 use in chronic viral infection settings.

Outcome

Cataloged evidence base supporting immune-restoration profile.

Camerini & Garaci, Expert Opin Biol Ther 2015;15 Suppl 1:S117–127
Handling Protocol

Storage Guidelines

CRL · STR-02

Lyophilized 2–8°C. Reconstituted: 2–8°C, 30 days.

Lyophilized
-20°C
Long-term, 24 months
Reconstituted
2–8°C
Refrigerated, 28 days
Light Exposure
Protect
Store in dark vial
Diluent
BAC Water
Sterile, 0.9% benzyl
Best practice — reconstitute with bacteriostatic water, swirl gently, do not shake.
Regulatory Notice

Research Disclaimer

CRL · REG-03
Research Use Only

Strictly for in-vitro laboratory and research investigations.

Not For Human Use

Not approved for diagnostic, therapeutic, or veterinary application.

Qualified Personnel

Handling restricted to licensed researchers and laboratory staff.

Warning — Thymosin Alpha-1 is supplied solely for legitimate laboratory research. Any administration to humans or animals is strictly prohibited and may violate federal, state, or local law. By purchasing, the researcher accepts full responsibility for safe handling, storage, and lawful use.

Document · CRL-REG-03Revision 2026.06 · Clinical Research Labs
Representative Literature

Citations & References

CRL · REF-04
  1. 03
    Camerini R, Garaci E. · 2015
    Historical review of thymosin α 1 in infectious diseases
    Expert Opin Biol Ther. 15 Suppl 1:S117–127.
References are representative of peer-reviewed literature and are provided for research context only.
Document · CRL-REF-04Revision 2026.06 · Clinical Research Labs