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TB-500 3ml vial label
RecoveryPurity 99.2%
Product profile

TB-500

Synthetic Thymosin Beta-4 fragment for repair research.

99.2%
Purity
Lyophilized
Form
-20°C
Storage
Research Use Only. Not for human or veterinary consumption, diagnostic, or therapeutic use.

What it is

TB-500 is a synthetic version of the active region of Thymosin β-4 used in soft-tissue research.

Pathway Diagram

Mechanism of Action

CRL · MOA-01

Binds G-actin, promoting cell migration and angiogenesis in in-vitro repair models.

  1. Step 01
    Receptor Binding

    Peptide engages target receptor with high affinity.

  2. Step 02
    Signal Cascade

    Downstream intracellular pathways activate.

  3. Step 03
    Cellular Response

    Gene expression and protein synthesis shift.

  4. Step 04
    Observed Outcome

    Measurable change in the studied biomarker.

Primary TargetsTissue repair researchAngiogenesisInflammation studies

Research highlights

Active fragment of Thymosin β-4 — actin-sequestering peptide.
Promotes cell migration, angiogenesis, and survival in injury models.
Cardiac progenitor activation observed in MI animal models.
Accelerates hair-follicle stem-cell activation in rodent dermal models.

Pharmacology snapshot

888 Da
Molecular weight
~2 hours (research models)
Half-life
SC / IM (research)
Route (research)

Potential research applications

Tissue repair research
Angiogenesis
Inflammation studies

Case studies

In vivo14 days

Dermal wound healing

Cohort: Rodent full-thickness wound

Thymosin β-4 applied topically/systemically to standardized wound model.

Outcome

Accelerated re-epithelialization, contraction, and angiogenesis vs. vehicle.

Malinda et al., J Invest Dermatol 1999;113(3):364–368
In vivo21 days

Hair-follicle stem cell activation

Cohort: Mouse dermal model

Quantified follicle stem-cell recruitment under Tβ4 administration.

Outcome

Increased hair growth via documented stem-cell activation pathway.

Philp et al., FASEB J 2004;18(2):385–387
In vivo4 weeks

Cardiac repair after MI

Cohort: Mouse MI model

Tβ4 in post-MI cardiac repair, integrin-linked kinase signaling.

Outcome

Improved cardiomyocyte survival, migration, and functional recovery.

Bock-Marquette et al., Nature 2004;432(7016):466–472
Handling Protocol

Storage Guidelines

CRL · STR-02

Lyophilized -20°C.

Lyophilized
-20°C
Long-term, 24 months
Reconstituted
2–8°C
Refrigerated, 28 days
Light Exposure
Protect
Store in dark vial
Diluent
BAC Water
Sterile, 0.9% benzyl
Best practice — reconstitute with bacteriostatic water, swirl gently, do not shake.
Regulatory Notice

Research Disclaimer

CRL · REG-03
Research Use Only

Strictly for in-vitro laboratory and research investigations.

Not For Human Use

Not approved for diagnostic, therapeutic, or veterinary application.

Qualified Personnel

Handling restricted to licensed researchers and laboratory staff.

Warning — TB-500 is supplied solely for legitimate laboratory research. Any administration to humans or animals is strictly prohibited and may violate federal, state, or local law. By purchasing, the researcher accepts full responsibility for safe handling, storage, and lawful use.

Document · CRL-REG-03Revision 2026.06 · Clinical Research Labs
Representative Literature

Citations & References

CRL · REF-04
  1. 01
    Malinda KM, Sidhu GS, Mani H, et al. · 1999
    Thymosin beta4 accelerates wound healing
    Journal of Investigative Dermatology. 113(3):364–368.
References are representative of peer-reviewed literature and are provided for research context only.
Document · CRL-REF-04Revision 2026.06 · Clinical Research Labs