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SNAP-8 3ml vial label
Skin & AestheticPurity 99.0%
Product profile

SNAP-8

Octapeptide for SNARE-pathway cosmetic research.

99.0%
Purity
Lyophilized
Form
-20°C
Storage
Research Use Only. Not for human or veterinary consumption, diagnostic, or therapeutic use.

What it is

SNAP-8 is an octapeptide analogue of the N-terminal region of SNAP-25 investigated for topical cosmetic research targeting expression-line attenuation.

Pathway Diagram

Mechanism of Action

CRL · MOA-01

Competes with SNAP-25 in the SNARE complex, reducing catecholamine-mediated neurotransmitter release in cultured neuronal models.

  1. Step 01
    Receptor Binding

    Peptide engages target receptor with high affinity.

  2. Step 02
    Signal Cascade

    Downstream intracellular pathways activate.

  3. Step 03
    Cellular Response

    Gene expression and protein synthesis shift.

  4. Step 04
    Observed Outcome

    Measurable change in the studied biomarker.

Primary TargetsTopical anti-wrinkle researchSNARE pathway studiesDermal-formulation research

Research highlights

Octapeptide elongation of Argireline (acetyl hexapeptide).
Competes with SNAP-25 in SNARE complex assembly.
Reduces depth of expression lines in topical-formulation research.
Cosmetic-only — not for parenteral research.

Pharmacology snapshot

894.0 Da
Molecular weight
Topical (skin retention varies by vehicle)
Half-life
Topical only (cosmetic research)
Route (research)
Sequence
Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2

Potential research applications

Topical anti-wrinkle research
SNARE pathway studies
Dermal-formulation research

Case studies

Clinical30 days

Argireline anti-wrinkle pharmacology

Cohort: Adult women

Foundational anti-wrinkle pharmacology of SNAP-25-derived peptides.

Outcome

Reduction in wrinkle depth at periorbital region vs. baseline.

Blanes-Mira et al., Int J Cosmet Sci 2002;24(5):303–310
ClinicalMulti-week

Argireline cosmetic efficacy

Cohort: Adult cohort

Reviewed clinical evidence on argireline-class peptide efficacy.

Outcome

Consistent modest improvements in expression-line metrics across trials.

Wang et al., Clin Drug Investig 2013;33(7):495–501
In vitroHours

Skin permeation of anti-wrinkle peptides

Cohort: Skin permeation assays

Tested permeation enhancement strategies for SNAP-class peptides.

Outcome

Demonstrated formulation-dependent stratum-corneum penetration.

Lim et al., Sci Rep 2022;12:9417
Handling Protocol

Storage Guidelines

CRL · STR-02

Store at 2–8°C in dry, light-protected containers.

Lyophilized
-20°C
Long-term, 24 months
Reconstituted
2–8°C
Refrigerated, 28 days
Light Exposure
Protect
Store in dark vial
Diluent
BAC Water
Sterile, 0.9% benzyl
Best practice — reconstitute with bacteriostatic water, swirl gently, do not shake.
Regulatory Notice

Research Disclaimer

CRL · REG-03
Research Use Only

Strictly for in-vitro laboratory and research investigations.

Not For Human Use

Not approved for diagnostic, therapeutic, or veterinary application.

Qualified Personnel

Handling restricted to licensed researchers and laboratory staff.

Warning — SNAP-8 is supplied solely for legitimate laboratory research. Any administration to humans or animals is strictly prohibited and may violate federal, state, or local law. By purchasing, the researcher accepts full responsibility for safe handling, storage, and lawful use.

Document · CRL-REG-03Revision 2026.06 · Clinical Research Labs
Representative Literature

Citations & References

CRL · REF-04
  1. 01
    Blanes-Mira C, Clemente J, Jodas G, et al. · 2002
    A synthetic hexapeptide (Argireline) with antiwrinkle activity
    Int J Cosmet Sci. 24(5):303–310.
  2. 02
References are representative of peer-reviewed literature and are provided for research context only.
Document · CRL-REF-04Revision 2026.06 · Clinical Research Labs