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Sermorelin 3ml vial label
Growth HormonePurity 99.2%
Product profile

Sermorelin

GHRH(1-29) analogue for endogenous GH research.

99.2%
Purity
Lyophilized
Form
-20°C
Storage
Research Use Only. Not for human or veterinary consumption, diagnostic, or therapeutic use.

What it is

Sermorelin is a synthetic 29-amino-acid analogue of growth-hormone-releasing hormone, the shortest fragment retaining full biological activity.

Pathway Diagram

Mechanism of Action

CRL · MOA-01

Binds pituitary GHRH receptors to stimulate endogenous, pulsatile GH release under physiological feedback.

  1. Step 01
    Receptor Binding

    Peptide engages target receptor with high affinity.

  2. Step 02
    Signal Cascade

    Downstream intracellular pathways activate.

  3. Step 03
    Cellular Response

    Gene expression and protein synthesis shift.

  4. Step 04
    Observed Outcome

    Measurable change in the studied biomarker.

Primary TargetsGH/IGF-1 axis researchPituitary stimulation testingAging-axis studies

Research highlights

Shortest GHRH fragment retaining full biological activity (residues 1-29).
Stimulates endogenous pulsatile GH via pituitary GHRH receptors.
Subject to physiological somatostatin feedback regulation.
Used in pediatric GH-deficiency and adult-onset GH research.

Pharmacology snapshot

3358 Da
Molecular weight
~11–12 minutes
Half-life
SC / IV (research)
Route (research)

Potential research applications

GH/IGF-1 axis research
Pituitary stimulation testing
Aging-axis studies
Pediatric GH research

Case studies

Preclinical

Sermorelin in adult-onset GH insufficiency

Cohort: Cross-trial synthesis

Reviewed sermorelin as alternative to recombinant GH in adult-onset deficiency.

Outcome

Supported pulsatile-GH advantage and preserved feedback regulation.

Walker, Clin Interv Aging 2006;1(4):307–308
Clinical16 weeks

Long-term GHRH(1-29) in older adults

Cohort: Age-advanced men and women

Long-term [Nle27]-GHRH(1-29) on endocrine and metabolic markers.

Outcome

Restored GH/IGF-1 toward younger-adult range with metabolic improvements.

Khorram et al., JCEM 1997;82(5):1472–1479
Clinical6 weeks

Nightly GHRH(1-29) in elderly men

Cohort: Healthy older men

Single nightly injections of GHRH(1-29) in healthy elderly men.

Outcome

Increased nocturnal GH pulses and IGF-1 vs. placebo.

Vittone et al., Metabolism 1997;46(1):89–96
Handling Protocol

Storage Guidelines

CRL · STR-02

Lyophilized 2–8°C. Reconstituted: 2–8°C, 14 days.

Lyophilized
-20°C
Long-term, 24 months
Reconstituted
2–8°C
Refrigerated, 28 days
Light Exposure
Protect
Store in dark vial
Diluent
BAC Water
Sterile, 0.9% benzyl
Best practice — reconstitute with bacteriostatic water, swirl gently, do not shake.
Regulatory Notice

Research Disclaimer

CRL · REG-03
Research Use Only

Strictly for in-vitro laboratory and research investigations.

Not For Human Use

Not approved for diagnostic, therapeutic, or veterinary application.

Qualified Personnel

Handling restricted to licensed researchers and laboratory staff.

Warning — Sermorelin is supplied solely for legitimate laboratory research. Any administration to humans or animals is strictly prohibited and may violate federal, state, or local law. By purchasing, the researcher accepts full responsibility for safe handling, storage, and lawful use.

Document · CRL-REG-03Revision 2026.06 · Clinical Research Labs
Representative Literature

Citations & References

CRL · REF-04
References are representative of peer-reviewed literature and are provided for research context only.
Document · CRL-REF-04Revision 2026.06 · Clinical Research Labs