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Semax 3ml vial label
CognitivePurity 99.1%
Product profile

Semax

ACTH-derived heptapeptide for neuroresearch.

99.1%
Purity
Lyophilized
Form
-20°C
Storage
Research Use Only. Not for human or veterinary consumption, diagnostic, or therapeutic use.

What it is

Semax is a synthetic heptapeptide analogue of an ACTH(4-10) fragment used in neuroscience research.

Pathway Diagram

Mechanism of Action

CRL · MOA-01

Modulates BDNF and dopaminergic/serotonergic systems in central nervous-system models.

  1. Step 01
    Receptor Binding

    Peptide engages target receptor with high affinity.

  2. Step 02
    Signal Cascade

    Downstream intracellular pathways activate.

  3. Step 03
    Cellular Response

    Gene expression and protein synthesis shift.

  4. Step 04
    Observed Outcome

    Measurable change in the studied biomarker.

Primary TargetsNeurotrophic signalingCognitive modelingNeuroprotection studies

Research highlights

Heptapeptide ACTH(4-10) analogue with central nervous-system activity.
Up-regulates BDNF and NGF expression in cortical neurons.
Neuroprotective in rodent focal cerebral ischemia.
Investigated for cognitive and stroke-recovery research.

Pharmacology snapshot

813.9 Da
Molecular weight
Minutes (rapid CSF penetration via intranasal)
Half-life
Intranasal (research)
Route (research)
Sequence
Met-Glu-His-Phe-Pro-Gly-Pro

Potential research applications

Neurotrophic signaling
Cognitive modeling
Neuroprotection studies

Case studies

In vivo72 hours

Focal ischemia gene expression

Cohort: Rat MCAO model

Transcriptomic analysis of immune and vascular pathways under Semax following focal ischemia.

Outcome

Attenuated pro-inflammatory cascade and modulated vascular remodeling genes.

Medvedeva et al., Dokl Biol Sci 2014;459:291–294
In vivo24–72 hours

Neurotrophin transcription post-ischemia

Cohort: Rat cerebral ischemia

Measured BDNF/NGF transcription under Semax and Pro-Gly-Pro after cerebral ischemia.

Outcome

Activated neurotrophin and receptor gene transcription in penumbral tissue.

Dmitrieva et al., Cell Mol Neurobiol 2010;30(1):71–79
Preclinical

Nootropic mechanism review

Cohort: Rodent cognitive models

Reviewed molecular substrates of Semax's nootropic effects across studies.

Outcome

Converging evidence for BDNF up-regulation and dopaminergic modulation.

Stavchansky et al., Biochem Mosc Suppl B 2014;8(3):216–223
Handling Protocol

Storage Guidelines

CRL · STR-02

Lyophilized -20°C.

Lyophilized
-20°C
Long-term, 24 months
Reconstituted
2–8°C
Refrigerated, 28 days
Light Exposure
Protect
Store in dark vial
Diluent
BAC Water
Sterile, 0.9% benzyl
Best practice — reconstitute with bacteriostatic water, swirl gently, do not shake.
Regulatory Notice

Research Disclaimer

CRL · REG-03
Research Use Only

Strictly for in-vitro laboratory and research investigations.

Not For Human Use

Not approved for diagnostic, therapeutic, or veterinary application.

Qualified Personnel

Handling restricted to licensed researchers and laboratory staff.

Warning — Semax is supplied solely for legitimate laboratory research. Any administration to humans or animals is strictly prohibited and may violate federal, state, or local law. By purchasing, the researcher accepts full responsibility for safe handling, storage, and lawful use.

Document · CRL-REG-03Revision 2026.06 · Clinical Research Labs
Representative Literature

Citations & References

CRL · REF-04
  1. 02
  2. 03
    Stavchansky VV, Yuzhakov VV, Botsina AY, et al. · 2014
    Molecular mechanisms of the nootropic action of Semax
    Biochemistry (Moscow) Supplement Series B. 8(3):216–223.
References are representative of peer-reviewed literature and are provided for research context only.
Document · CRL-REF-04Revision 2026.06 · Clinical Research Labs