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Selank 3ml vial label
CognitivePurity 99.0%
Product profile

Selank

Tuftsin-derived peptide studied for neuromodulation.

99.0%
Purity
Lyophilized
Form
-20°C
Storage
Research Use Only. Not for human or veterinary consumption, diagnostic, or therapeutic use.

What it is

Selank is a synthetic analogue of the immunomodulatory peptide tuftsin used in central-nervous-system research.

Pathway Diagram

Mechanism of Action

CRL · MOA-01

Influences GABAergic and serotonergic systems and modulates expression of BDNF in research models.

  1. Step 01
    Receptor Binding

    Peptide engages target receptor with high affinity.

  2. Step 02
    Signal Cascade

    Downstream intracellular pathways activate.

  3. Step 03
    Cellular Response

    Gene expression and protein synthesis shift.

  4. Step 04
    Observed Outcome

    Measurable change in the studied biomarker.

Primary TargetsAnxiety modelingNeuroimmune researchCognitive performance studies

Research highlights

Synthetic tuftsin analogue with anxiolytic activity in rodent models.
Modulates GABA-A receptor sensitivity and serotonin turnover.
Influences enkephalin degradation — extended endogenous opioid signaling.
Investigated for generalized anxiety in Russian clinical work.

Pharmacology snapshot

751.9 Da
Molecular weight
Minutes (intranasal CNS uptake)
Half-life
Intranasal (research)
Route (research)
Sequence
Thr-Lys-Pro-Arg-Pro-Gly-Pro

Potential research applications

Anxiety modeling
Neuroimmune research
Cognitive performance studies

Case studies

In vivoAcute

GABAergic transmission gene panel

Cohort: Rat hippocampus

Profiled GABA-system gene expression in hippocampus after Selank exposure.

Outcome

Up-regulated GABA-A subunit transcription consistent with anxiolytic phenotype.

Volkova et al., Front Pharmacol 2016;7:31
In vivo10 days

BDNF expression in stress models

Cohort: Rat behavioral stress cohort

Behavior and BDNF mRNA quantified under chronic Selank dosing.

Outcome

Normalized exploratory behavior and increased hippocampal BDNF transcription.

Umarova et al., Bull Exp Biol Med 2009;147(3):302–305
In vivo3 weeks

Cholinergic-lesion cognition

Cohort: Rats with cholinergic lesion

Cognitive performance under Selank after chemical cholinergic disruption.

Outcome

Partial recovery of learning/memory tasks vs. lesioned controls.

Semenova et al., Bull Exp Biol Med 2007;144(4):547–549
Handling Protocol

Storage Guidelines

CRL · STR-02

Lyophilized -20°C.

Lyophilized
-20°C
Long-term, 24 months
Reconstituted
2–8°C
Refrigerated, 28 days
Light Exposure
Protect
Store in dark vial
Diluent
BAC Water
Sterile, 0.9% benzyl
Best practice — reconstitute with bacteriostatic water, swirl gently, do not shake.
Regulatory Notice

Research Disclaimer

CRL · REG-03
Research Use Only

Strictly for in-vitro laboratory and research investigations.

Not For Human Use

Not approved for diagnostic, therapeutic, or veterinary application.

Qualified Personnel

Handling restricted to licensed researchers and laboratory staff.

Warning — Selank is supplied solely for legitimate laboratory research. Any administration to humans or animals is strictly prohibited and may violate federal, state, or local law. By purchasing, the researcher accepts full responsibility for safe handling, storage, and lawful use.

Document · CRL-REG-03Revision 2026.06 · Clinical Research Labs
Representative Literature

Citations & References

CRL · REF-04
  1. 02
    Umarova BA, Lelekova TV, Kopylova GN, et al. · 2009
    Effects of selank on the behavior and BDNF gene expression in rats
    Bulletin of Experimental Biology and Medicine. 147(3):302–305.
  2. 03
    Semenova TP, Kozlovskaya MM, Zuikov AV, et al. · 2007
    Effect of Selank on cognitive processes after damage inflicted to the cholinergic system in the brain
    Bulletin of Experimental Biology and Medicine. 144(4):547–549.
References are representative of peer-reviewed literature and are provided for research context only.
Document · CRL-REF-04Revision 2026.06 · Clinical Research Labs