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Melanotan 2 (MT-2) 3ml vial label
Skin & AestheticPurity 99.0%
Product profile

Melanotan 2 (MT-2)

Synthetic α-MSH analogue for melanocortin-system research.

99.0%
Purity
Lyophilized
Form
-20°C
Storage
Research Use Only. Not for human or veterinary consumption, diagnostic, or therapeutic use.

What it is

Melanotan 2 is a cyclic synthetic analogue of α-melanocyte-stimulating hormone used in research of melanocortin receptors and pigmentation pathways.

Pathway Diagram

Mechanism of Action

CRL · MOA-01

Non-selective melanocortin receptor agonist (MC1R, MC3R, MC4R, MC5R) influencing melanogenesis and central appetite/arousal pathways.

  1. Step 01
    Receptor Binding

    Peptide engages target receptor with high affinity.

  2. Step 02
    Signal Cascade

    Downstream intracellular pathways activate.

  3. Step 03
    Cellular Response

    Gene expression and protein synthesis shift.

  4. Step 04
    Observed Outcome

    Measurable change in the studied biomarker.

Primary TargetsMelanogenesis researchMC4R/appetite studiesSexual function research

Research highlights

Cyclic α-MSH analogue with superpotent melanocortin activity.
Activates MC1R (pigmentation), MC3R/MC4R (appetite/sexual behavior), MC5R.
Induces erections in psychogenic-ED research populations.
Pan-MCR engagement underlies broad research profile.

Pharmacology snapshot

1024.2 Da
Molecular weight
~33 minutes
Half-life
SC (research)
Route (research)
Sequence
Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2

Potential research applications

Melanogenesis research
MC4R/appetite studies
Sexual function research
Photoprotection models

Case studies

ClinicalMultiple doses

Phase 1 superpotent melanotropin

Cohort: Healthy adults

First human clinical evaluation of MT-II tanning response and safety.

Outcome

Reproducible increase in melanin density with manageable side-effect profile.

Dorr et al., Life Sci 1996;58(20):1777–1784
ClinicalAcute dosing

Psychogenic erectile dysfunction

Cohort: Men with psychogenic ED

Tested MT-II on erectile response in psychogenic ED population.

Outcome

Significant erectile response vs. placebo confirming central MC4R activity.

Wessells et al., J Urol 1998;160(2):389–393
Preclinical

Melanocortin therapeutics review

Cohort: Cross-program synthesis

Historical and commercial review of melanocortin peptide therapeutics.

Outcome

Established pan-MCR class as productive research/clinical pathway.

Hadley & Dorr, Peptides 2006;27(4):921–930
Handling Protocol

Storage Guidelines

CRL · STR-02

Lyophilized -20°C, light-protected.

Lyophilized
-20°C
Long-term, 24 months
Reconstituted
2–8°C
Refrigerated, 28 days
Light Exposure
Protect
Store in dark vial
Diluent
BAC Water
Sterile, 0.9% benzyl
Best practice — reconstitute with bacteriostatic water, swirl gently, do not shake.
Regulatory Notice

Research Disclaimer

CRL · REG-03
Research Use Only

Strictly for in-vitro laboratory and research investigations.

Not For Human Use

Not approved for diagnostic, therapeutic, or veterinary application.

Qualified Personnel

Handling restricted to licensed researchers and laboratory staff.

Warning — Melanotan 2 (MT-2) is supplied solely for legitimate laboratory research. Any administration to humans or animals is strictly prohibited and may violate federal, state, or local law. By purchasing, the researcher accepts full responsibility for safe handling, storage, and lawful use.

Document · CRL-REG-03Revision 2026.06 · Clinical Research Labs
Representative Literature

Citations & References

CRL · REF-04
References are representative of peer-reviewed literature and are provided for research context only.
Document · CRL-REF-04Revision 2026.06 · Clinical Research Labs