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Kisspeptin-10 3ml vial label
Sexual HealthPurity 99.2%
Product profile

Kisspeptin-10

Hypothalamic decapeptide regulating reproductive axis.

99.2%
Purity
Lyophilized
Form
-20°C
Storage
Research Use Only. Not for human or veterinary consumption, diagnostic, or therapeutic use.

What it is

Kisspeptin-10 is the C-terminal decapeptide of kisspeptin, a key upstream regulator of GnRH neurons and the hypothalamic-pituitary-gonadal axis.

Pathway Diagram

Mechanism of Action

CRL · MOA-01

Agonizes the KISS1R/GPR54 receptor on GnRH neurons, stimulating gonadotropin release.

  1. Step 01
    Receptor Binding

    Peptide engages target receptor with high affinity.

  2. Step 02
    Signal Cascade

    Downstream intracellular pathways activate.

  3. Step 03
    Cellular Response

    Gene expression and protein synthesis shift.

  4. Step 04
    Observed Outcome

    Measurable change in the studied biomarker.

Primary TargetsHPG-axis researchPuberty modelingReproductive endocrinology

Research highlights

C-terminal decapeptide of KISS1-derived kisspeptin family.
Most potent endogenous activator of GnRH neurons.
Loss-of-function KISS1R mutations cause hypogonadotropic hypogonadism.
Used as diagnostic and research tool for HPG-axis evaluation.

Pharmacology snapshot

1302.5 Da
Molecular weight
~4 minutes
Half-life
IV / SC bolus (research)
Route (research)
Sequence
Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2

Potential research applications

HPG-axis research
Puberty modeling
Reproductive endocrinology
Fertility research

Case studies

ClinicalAcute

Kisspeptin-54 stimulates HPG axis

Cohort: Healthy men

First human study of kisspeptin on LH/FSH/testosterone secretion.

Outcome

Dose-dependent LH and testosterone elevation following IV kisspeptin.

Dhillo et al., JCEM 2005;90(12):6609–6615
Clinical—

KISS1R loss-of-function

Cohort: Consanguineous HH family

Genetic study identifying GPR54/KISS1R mutations in HH.

Outcome

Established kisspeptin signaling as essential for HPG-axis function.

de Roux et al., PNAS 2003;100(19):10972–10976
ClinicalAcute

LH pulsatility in women

Cohort: Healthy women across cycle

Single kisspeptin-54 injection on LH pulse pattern in women.

Outcome

Temporarily increased LH pulse frequency without altering pulse amplitude.

Jayasena et al., Clin Endocrinol 2013;79(4):558–563
Handling Protocol

Storage Guidelines

CRL · STR-02

Lyophilized -20°C, light-protected.

Lyophilized
-20°C
Long-term, 24 months
Reconstituted
2–8°C
Refrigerated, 28 days
Light Exposure
Protect
Store in dark vial
Diluent
BAC Water
Sterile, 0.9% benzyl
Best practice — reconstitute with bacteriostatic water, swirl gently, do not shake.
Regulatory Notice

Research Disclaimer

CRL · REG-03
Research Use Only

Strictly for in-vitro laboratory and research investigations.

Not For Human Use

Not approved for diagnostic, therapeutic, or veterinary application.

Qualified Personnel

Handling restricted to licensed researchers and laboratory staff.

Warning — Kisspeptin-10 is supplied solely for legitimate laboratory research. Any administration to humans or animals is strictly prohibited and may violate federal, state, or local law. By purchasing, the researcher accepts full responsibility for safe handling, storage, and lawful use.

Document · CRL-REG-03Revision 2026.06 · Clinical Research Labs
Representative Literature

Citations & References

CRL · REF-04
  1. 01
    Dhillo WS, Chaudhri OB, Patterson M, et al. · 2005
    Kisspeptin-54 stimulates the hypothalamic-pituitary-gonadal axis in human males
    J Clin Endocrinol Metab. 90(12):6609–6615.
    DOI · 10.1210/jc.2005-1468PMID · 16174713
  2. 02
    de Roux N, Genin E, Carel JC, et al. · 2003
    Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54
    PNAS. 100(19):10972–10976.
    DOI · 10.1073/pnas.1834399100PMID · 12944565
  3. 03
    Jayasena CN, Comninos AN, Veldhuis JD, et al. · 2013
    A single injection of kisspeptin-54 temporarily increases luteinizing hormone pulsatility in healthy women
    Clin Endocrinol. 79(4):558–563.
    DOI · 10.1111/cen.12179PMID · 23452073
References are representative of peer-reviewed literature and are provided for research context only.
Document · CRL-REF-04Revision 2026.06 · Clinical Research Labs