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HCG 3ml vial label
Sexual HealthPurity ≥98%
Product profile

HCG

Human chorionic gonadotropin for reproductive endocrinology research.

≥98%
Purity
Lyophilized
Form
-20°C
Storage
Research Use Only. Not for human or veterinary consumption, diagnostic, or therapeutic use.

What it is

Human chorionic gonadotropin (hCG) is a glycoprotein hormone studied in reproductive endocrinology and gonadal-axis research.

Pathway Diagram

Mechanism of Action

CRL · MOA-01

Binds the LH/CG receptor to stimulate steroidogenesis in gonadal cells.

  1. Step 01
    Receptor Binding

    Peptide engages target receptor with high affinity.

  2. Step 02
    Signal Cascade

    Downstream intracellular pathways activate.

  3. Step 03
    Cellular Response

    Gene expression and protein synthesis shift.

  4. Step 04
    Observed Outcome

    Measurable change in the studied biomarker.

Primary TargetsSteroidogenesis researchSpermatogenesis studiesOvulation modeling

Research highlights

Glycoprotein hormone with α/β subunits; β-subunit confers LH/CG-receptor specificity.
Maintains intratesticular testosterone during exogenous androgen suppression.
Sustains spermatogenesis in hypogonadotropic hypogonadism research.
Used to induce ovulation in reproductive research models.

Pharmacology snapshot

~36,700 Da (glycosylated)
Molecular weight
~33 hours (terminal)
Half-life
SC / IM (research)
Route (research)

Potential research applications

Steroidogenesis research
Spermatogenesis studies
Ovulation modeling
HPG-axis recovery

Case studies

Preclinical—

Biological functions review

Cohort: Cross-tissue synthesis

Comprehensive review of hCG isoforms and biological functions.

Outcome

Established distinct roles for hyperglycosylated and pituitary hCG.

Cole, Reprod Biol Endocrinol 2010;8:102
Clinical3 weeks

Intratesticular testosterone maintenance

Cohort: Healthy men with TRT-induced suppression

Low-dose hCG vs. placebo on intratesticular testosterone.

Outcome

Maintained intratesticular T at near-baseline despite full gonadotropin suppression.

Coviello et al., JCEM 2005;90(5):2595–2602
ClinicalUp to 12 months

Spermatogenesis with hCG alone

Cohort: Men with hypogonadotropic hypogonadism

Evaluated hCG monotherapy on sperm production in HH.

Outcome

Restored or maintained spermatogenesis in subset of HH patients.

Depenbusch et al., Eur J Endocrinol 2002;147(5):617–624
Handling Protocol

Storage Guidelines

CRL · STR-02

Lyophilized -20°C. Reconstituted: 2–8°C, 30 days.

Lyophilized
-20°C
Long-term, 24 months
Reconstituted
2–8°C
Refrigerated, 28 days
Light Exposure
Protect
Store in dark vial
Diluent
BAC Water
Sterile, 0.9% benzyl
Best practice — reconstitute with bacteriostatic water, swirl gently, do not shake.
Regulatory Notice

Research Disclaimer

CRL · REG-03
Research Use Only

Strictly for in-vitro laboratory and research investigations.

Not For Human Use

Not approved for diagnostic, therapeutic, or veterinary application.

Qualified Personnel

Handling restricted to licensed researchers and laboratory staff.

Warning — HCG is supplied solely for legitimate laboratory research. Any administration to humans or animals is strictly prohibited and may violate federal, state, or local law. By purchasing, the researcher accepts full responsibility for safe handling, storage, and lawful use.

Document · CRL-REG-03Revision 2026.06 · Clinical Research Labs
Representative Literature

Citations & References

CRL · REF-04
  1. 01
    Cole LA. · 2010
    Biological functions of hCG and hCG-related molecules
    Reprod Biol Endocrinol. 8:102.
    DOI · 10.1186/1477-7827-8-102PMID · 20735820
  2. 02
    Coviello AD, Matsumoto AM, Bremner WJ, et al. · 2005
    Low-dose human chorionic gonadotropin maintains intratesticular testosterone in normal men with testosterone-induced gonadotropin suppression
    J Clin Endocrinol Metab. 90(5):2595–2602.
    DOI · 10.1210/jc.2004-0802PMID · 15713727
  3. 03
    Depenbusch M, von Eckardstein S, Simoni M, Nieschlag E. · 2002
    Maintenance of spermatogenesis in hypogonadotropic hypogonadal men with human chorionic gonadotropin alone
    Eur J Endocrinol. 147(5):617–624.
    DOI · 10.1530/eje.0.1470617PMID · 12444894
References are representative of peer-reviewed literature and are provided for research context only.
Document · CRL-REF-04Revision 2026.06 · Clinical Research Labs