Back to catalog
GHK Basic 3ml vial label
Skin & AestheticPurity 99.4%
Product profile

GHK Basic

Copper-free GHK tripeptide for ECM and skin research.

99.4%
Purity
Lyophilized
Form
-20°C
Storage
Research Use Only. Not for human or veterinary consumption, diagnostic, or therapeutic use.

What it is

GHK is the copper-free form of the endogenous tripeptide glycyl-L-histidyl-L-lysine, used to study tissue-remodeling and ECM signaling without copper-binding effects.

Pathway Diagram

Mechanism of Action

CRL · MOA-01

Modulates expression of genes involved in collagen, glycosaminoglycan and antioxidant pathways independently of copper transport.

  1. Step 01
    Receptor Binding

    Peptide engages target receptor with high affinity.

  2. Step 02
    Signal Cascade

    Downstream intracellular pathways activate.

  3. Step 03
    Cellular Response

    Gene expression and protein synthesis shift.

  4. Step 04
    Observed Outcome

    Measurable change in the studied biomarker.

Primary TargetsFibroblast researchWound-healing modelsECM remodeling

Research highlights

Endogenous tripeptide; plasma levels decline with age (~10 ng/mL young → ~2 ng/mL by 60).
Activates >4000 genes associated with regenerative and antioxidant pathways.
Promotes collagen, decorin and GAG synthesis in fibroblasts.
Operates without copper binding — distinct profile from GHK-Cu.

Pharmacology snapshot

340.4 Da
Molecular weight
Short (rapid clearance)
Half-life
Topical / SC (research)
Route (research)
Sequence
Gly-His-Lys

Potential research applications

Fibroblast research
Wound-healing models
ECM remodeling
Cosmetic-formulation research

Case studies

In vitroWeeks

GHK in skin regeneration

Cohort: Human dermal fibroblasts

Characterized GHK effects on collagen, elastin and antioxidant pathways.

Outcome

Up-regulated dermal ECM proteins with parallel antioxidant gene induction.

Pickart et al., BioMed Res Int 2015;2015:648108
Preclinical

Regenerative gene-modulation review

Cohort: Cross-tissue synthesis

Reviewed transcriptomic and regenerative effects of GHK and GHK-Cu.

Outcome

Documented broad gene-regulatory effect of GHK family on repair pathways.

Pickart & Margolina, IJMS 2018;19(7):1987
Preclinical

GHK and tissue remodeling

Cohort: Cross-tissue synthesis

Foundational review of GHK in connective-tissue remodeling.

Outcome

Established GHK as endogenous modulator of repair and remodeling pathways.

Pickart, J Biomater Sci Polym Ed 2008;19(8):969–988
Handling Protocol

Storage Guidelines

CRL · STR-02

Lyophilized -20°C. Reconstituted: refrigerate, 30 days.

Lyophilized
-20°C
Long-term, 24 months
Reconstituted
2–8°C
Refrigerated, 28 days
Light Exposure
Protect
Store in dark vial
Diluent
BAC Water
Sterile, 0.9% benzyl
Best practice — reconstitute with bacteriostatic water, swirl gently, do not shake.
Regulatory Notice

Research Disclaimer

CRL · REG-03
Research Use Only

Strictly for in-vitro laboratory and research investigations.

Not For Human Use

Not approved for diagnostic, therapeutic, or veterinary application.

Qualified Personnel

Handling restricted to licensed researchers and laboratory staff.

Warning — GHK Basic is supplied solely for legitimate laboratory research. Any administration to humans or animals is strictly prohibited and may violate federal, state, or local law. By purchasing, the researcher accepts full responsibility for safe handling, storage, and lawful use.

Document · CRL-REG-03Revision 2026.06 · Clinical Research Labs
Representative Literature

Citations & References

CRL · REF-04
References are representative of peer-reviewed literature and are provided for research context only.
Document · CRL-REF-04Revision 2026.06 · Clinical Research Labs