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DSIP 3ml vial label
SleepPurity 99.0%
Product profile

DSIP

Delta-Sleep Inducing Peptide for sleep & stress research.

99.0%
Purity
Lyophilized
Form
-20°C
Storage
Research Use Only. Not for human or veterinary consumption, diagnostic, or therapeutic use.

What it is

DSIP is a nonapeptide first isolated from the cerebral venous blood of rabbits during electrically induced sleep, used in sleep and stress research.

Pathway Diagram

Mechanism of Action

CRL · MOA-01

Modulates EEG delta activity, HPA-axis output, and opioid/monoaminergic systems in CNS research models.

  1. Step 01
    Receptor Binding

    Peptide engages target receptor with high affinity.

  2. Step 02
    Signal Cascade

    Downstream intracellular pathways activate.

  3. Step 03
    Cellular Response

    Gene expression and protein synthesis shift.

  4. Step 04
    Observed Outcome

    Measurable change in the studied biomarker.

Primary TargetsSleep architecture researchHPA-axis modulationStress recovery models

Research highlights

Nonapeptide isolated from cerebral venous blood during induced sleep.
Crosses the blood-brain barrier rapidly.
Modulates EEG delta-wave activity in animal and human studies.
Reduces stress-induced ACTH/corticosterone in rodent models.

Pharmacology snapshot

848.8 Da
Molecular weight
~7 minutes (rapid CNS uptake)
Half-life
SC / IV (research)
Route (research)
Sequence
Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu

Potential research applications

Sleep architecture research
HPA-axis modulation
Stress recovery models
Neuroendocrine studies

Case studies

Preclinical

DSIP characterization & multivariate function

Cohort: Cross-species cohort

Foundational pharmacology review across CNS and endocrine systems.

Outcome

Established DSIP as a multifunctional neuropeptide with sleep and stress effects.

Schoenenberger, Eur Neurol 1984;23(5):321–345
Preclinical

DSIP unresolved-mechanism review

Cohort: Multi-model synthesis

Reviewed receptor-binding and sleep-modulating activity across decades of work.

Outcome

Catalogued documented neuroendocrine effects despite unclear primary receptor.

Kovalzon & Strekalova, J Neurochem 2006;97(2):303–309
Preclinical

DSIP update on biology

Cohort: Multi-model synthesis

Comprehensive update on DSIP biology including stress and circadian models.

Outcome

Documented anxiolytic-like and HPA-modulating activity profile.

Graf & Kastin, Peptides 1986;7(6):1165–1187
Handling Protocol

Storage Guidelines

CRL · STR-02

Lyophilized -20°C.

Lyophilized
-20°C
Long-term, 24 months
Reconstituted
2–8°C
Refrigerated, 28 days
Light Exposure
Protect
Store in dark vial
Diluent
BAC Water
Sterile, 0.9% benzyl
Best practice — reconstitute with bacteriostatic water, swirl gently, do not shake.
Regulatory Notice

Research Disclaimer

CRL · REG-03
Research Use Only

Strictly for in-vitro laboratory and research investigations.

Not For Human Use

Not approved for diagnostic, therapeutic, or veterinary application.

Qualified Personnel

Handling restricted to licensed researchers and laboratory staff.

Warning — DSIP is supplied solely for legitimate laboratory research. Any administration to humans or animals is strictly prohibited and may violate federal, state, or local law. By purchasing, the researcher accepts full responsibility for safe handling, storage, and lawful use.

Document · CRL-REG-03Revision 2026.06 · Clinical Research Labs
Representative Literature

Citations & References

CRL · REF-04
References are representative of peer-reviewed literature and are provided for research context only.
Document · CRL-REF-04Revision 2026.06 · Clinical Research Labs