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BPC-157 3ml vial label
RecoveryPurity 99.2%
Product profile

BPC-157

Body Protection Compound — soft tissue & gut research peptide.

99.2%
Purity
Lyophilized
Form
-20°C
Storage
Research Use Only. Not for human or veterinary consumption, diagnostic, or therapeutic use.

What it is

BPC-157 is a synthetic pentadecapeptide derived from a protein found in gastric juice, studied for its role in cellular repair pathways and angiogenesis modeling.

Pathway Diagram

Mechanism of Action

CRL · MOA-01

Modulates the VEGFR2-Akt-eNOS signaling cascade, promoting angiogenesis and accelerating in-vitro tissue regeneration models.

  1. Step 01
    Receptor Binding

    Peptide engages target receptor with high affinity.

  2. Step 02
    Signal Cascade

    Downstream intracellular pathways activate.

  3. Step 03
    Cellular Response

    Gene expression and protein synthesis shift.

  4. Step 04
    Observed Outcome

    Measurable change in the studied biomarker.

Primary TargetsTendon & ligament repair modelsGastrointestinal lining studiesAngiogenesis research

Research highlights

Pentadecapeptide stable in gastric juice — orally bioavailable in animal models.
Up-regulates VEGFR2-Akt-eNOS signaling driving angiogenesis.
Accelerates tendon, ligament, muscle and GI repair across rodent injury models.
Counteracts NSAID-induced lesions in preclinical studies.

Pharmacology snapshot

1419.5 Da
Molecular weight
~4 hours (research models)
Half-life
SC / IP / oral (research)
Route (research)
Sequence
GEPPPGKPADDAGLV

Potential research applications

Tendon & ligament repair models
Gastrointestinal lining studies
Angiogenesis research
Inflammation modulation

Case studies

In vivo14 days

Achilles tendon transection repair

Cohort: Rat tendon-injury model

Evaluated functional and histological recovery after Achilles tendon transection with daily BPC-157.

Outcome

Accelerated tenocyte outgrowth, improved load-to-failure and faster recovery of locomotion vs. saline.

Cerovecki et al., J Orthop Res 2010;28(9):1155–1161
In vivo21 days

Alkali-burn wound healing

Cohort: Rat dermal burn model

Topical and systemic BPC-157 on full-thickness alkali burns; angiogenesis assays in HUVEC parallel.

Outcome

Faster re-epithelialization, increased capillary density and enhanced fibroblast migration vs. control.

Huang et al., Drug Des Devel Ther 2015;9:2485–2499
PreclinicalMulti-week

GI ulcer protection

Cohort: Rodent ulcer & colitis models

Reviewed reproducible protective effect across cysteamine, ethanol, and indomethacin-induced GI lesions.

Outcome

Consistent mucosal protection and accelerated lesion resolution across independent labs.

Sikiric et al., Curr Pharm Des 2018;24(18):1992–2001
Handling Protocol

Storage Guidelines

CRL · STR-02

Store lyophilized at -20°C. Reconstituted: refrigerate at 2–8°C, use within 30 days.

Lyophilized
-20°C
Long-term, 24 months
Reconstituted
2–8°C
Refrigerated, 28 days
Light Exposure
Protect
Store in dark vial
Diluent
BAC Water
Sterile, 0.9% benzyl
Best practice — reconstitute with bacteriostatic water, swirl gently, do not shake.
Regulatory Notice

Research Disclaimer

CRL · REG-03
Research Use Only

Strictly for in-vitro laboratory and research investigations.

Not For Human Use

Not approved for diagnostic, therapeutic, or veterinary application.

Qualified Personnel

Handling restricted to licensed researchers and laboratory staff.

Warning — BPC-157 is supplied solely for legitimate laboratory research. Any administration to humans or animals is strictly prohibited and may violate federal, state, or local law. By purchasing, the researcher accepts full responsibility for safe handling, storage, and lawful use.

Document · CRL-REG-03Revision 2026.06 · Clinical Research Labs
Representative Literature

Citations & References

CRL · REF-04
  1. 01
    Sikiric P, Seiwerth S, Rucman R, et al. · 2018
    Stable gastric pentadecapeptide BPC 157: novel therapy in gastrointestinal tract
    Current Pharmaceutical Design. 24(18):1992–2001.
  2. 02
    Cerovecki I, Bojanic I, Brcic L, et al. · 2010
    Pentadecapeptide BPC 157 (PL 14736) improves ligament healing in the rat
    Journal of Orthopaedic Research. 28(9):1155–1161.
References are representative of peer-reviewed literature and are provided for research context only.
Document · CRL-REF-04Revision 2026.06 · Clinical Research Labs